In a high‑stakes investigation that has captured national attention, the FBI is now applying the latest DNA analysis techniques to a sample collected from the home of 84‑year‑old Nancy Guthrie, the mother of famed television anchor Savannah Guthrie. The effort comes as the disappearance of Nancy in February has left a community in shock and authorities racing to identify the suspect responsible for her abduction.
Background of the Case
On the morning of February 12, Nancy Guthrie was reported missing after a family member called 911. The call was followed by a grainy security‑camera image that showed a man in a ski mask standing on Nancy’s porch. No suspect has been named, and the case remains unsolved. Nancy’s disappearance has prompted a multi‑agency response, with the Pima County Sheriff’s Department, the FBI, and private forensic laboratories all working in tandem.
DNA Evidence and FBI Involvement
According to a statement released by the Pima County Sheriff’s Department, a private laboratory in Florida—an established partner of the sheriff’s office—recently forwarded a DNA sample to the FBI. The sample was taken from Nancy’s property and, as the sheriff’s statement clarified, does not belong to Nancy herself. The FBI is now employing advanced technology to analyze the DNA, hoping to trace it back to the individual who entered the home.
ABC News reported that the FBI has been involved “since the beginning” of the investigation, and the new DNA work is part of a broader strategy to identify the abductor. The FBI’s use of cutting‑edge forensic methods—such as next‑generation sequencing and probabilistic genotyping—could provide a clearer genetic profile than earlier analyses.
Collaboration Between Local and Federal Agencies
The partnership between the Pima County Sheriff’s Department and the FBI exemplifies how local and federal resources can be combined to tackle complex missing‑person cases. The sheriff’s office has maintained a steady flow of information to the FBI, ensuring that any new evidence is promptly shared with national databases. The private Florida lab, meanwhile, continues to provide forensic support, bridging the gap between on‑the‑ground collection and high‑level analysis.
In a recent statement to Us Weekly, the sheriff’s department emphasized that the DNA analysis is “ongoing” and that the investigation remains active. This collaborative approach underscores the seriousness with which authorities are treating Nancy’s case.
What the DNA Could Reveal
DNA evidence can be a powerful tool in missing‑person investigations. By comparing the genetic material found on Nancy’s property to national databases, investigators can:
- Identify potential matches to known offenders.
- Determine familial relationships that might point to a suspect’s relatives.
- Establish a genetic profile that can be used in future investigations.
Because the sample does not belong to Nancy, it is likely to come from the individual who entered her home. If the DNA matches a person already in the system, authorities could quickly narrow down the suspect pool. If no match is found, the FBI may still use the profile to generate leads, such as geographic profiling or behavioral analysis.
Current Status and Next Steps
As of the latest updates, the FBI’s advanced DNA analysis is still in progress. The Pima County Sheriff’s








